Gastrointestinal Chlamydia-Induced CD8⁺ T Cells Promote Chlamydial Pathogenicity in the Female Upper Genital Tract.

ABSTRACT: Chlamydia is known to both ascend to the upper genital tract and spread to the gastrointestinal tract following intravaginal inoculation. Gastrointestinal Chlamydia was recently reported to promote chlamydial pathogenicity in the genital tract since mice intravaginally inoculated with an attenuated Chlamydia strain, which alone failed to develop pathology in the genital tract, were restored to develop hydrosalpinx by intragastric coinoculation with wild-type Chlamydia. Gastrointestinal Chlamydia promoted hydrosalpinx via an indirect mechanism since Chlamydia in the gut did not directly spread to the genital tract lumen. In the current study, we further investigated the role of CD8⁺ T cells in the promotion of hydrosalpinx by gastrointestinal Chlamydia. First, we confirmed that i

SUBMITTER: Tian Q 

PROVIDER: S-EPMC8445165 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature