Effect of feedback regulation on stem cell fractions in tissues and tumors: Understanding chemoresistance in cancer.

ABSTRACT: While resistance mutations are often implicated in the failure of cancer therapy, lack of response also occurs without such mutants. In bladder cancer mouse xenografts, repeated chemotherapy cycles have resulted in cancer stem cell (CSC) enrichment, and consequent loss of therapy response due to the reduced susceptibility of CSCs to drugs. A particular feedback loop present in the xenografts has been shown to promote CSC enrichment in this system. Yet, many other regulatory loops might also be operational and might promote CSC enrichment. Their identification is central to improving therapy response. Here, we perform a comprehensive mathematical analysis to define what types of regulatory feedback loops can and cannot contribute to CSC enrichment, providing guidance to the experimental ide

SUBMITTER: Weiss LD 

PROVIDER: S-EPMC8445233 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature