Ontology highlight
ABSTRACT:
SUBMITTER: Chen YH
PROVIDER: S-EPMC8445329 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Chen Yi Han YH Wang Xin Yu XY Jin Xin X Yang Zi Z Xu Jianguang J
Frontiers in pharmacology 20210902
Primary Sjögren's syndrome (pSS) is a systemic autoimmune diseases of the connective tissues, characteristic of the presentation of keratoconjunctivitis sicca and xerostomia. A cardinal pathogenetic feature of SS is B-cell hyperactivity, which has invited efforts on optimal B-cell targeted therapy, whereas conventional corticosteroids and disease-modifying antirheumatic drugs (DMARDs) are restricted to symptomatic relief. As per the first EULAR recommendation for pSS patients published in 2020, ...[more]