Development and Validation of a Clinical Prognostic Nomogram for Esophageal Adenocarcinoma Patients.

ABSTRACT:

Background

Clinical staging is essential for clinical decisions but remains imprecise. We purposed to construct a novel survival prediction model for improving clinical staging system (cTNM) for patients with esophageal adenocarcioma (EAC).

Methods

A total of 4180 patients diagnosed with EAC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and included as the training cohort. Significant prognostic variables were identified for nomogram model development using multivariable Cox regression. The model was validated internally by bootstrap resampling, and then subjected to external validation with a separate cohort of 886 patients from 2 institutions in China. The prognostic performance was measured by concordance index (C-index), Akaike infor

SUBMITTER: Shao CY 

PROVIDER: S-EPMC8445330 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature