Blinded study: prospectively defined high-frequency oscillations predict seizure outcome in individual patients.

ABSTRACT: Interictal high-frequency oscillations are discussed as biomarkers for epileptogenic brain tissue that should be resected in epilepsy surgery to achieve seizure freedom. The prospective classification of tissue sampled by individual electrode contacts remains a challenge. We have developed an automated, prospective definition of clinically relevant high-frequency oscillations in intracranial EEG from Montreal and tested it in recordings from Zurich. We here validated the algorithm on intracranial EEG that was recorded in an independent epilepsy centre so that the analysis was blinded to seizure outcome. We selected consecutive patients who underwent resective epilepsy surgery in Geneva with post-surgical follow-up > 12 months. We analysed long-term recordings during sleep that we segmented

SUBMITTER: Dimakopoulos V 

PROVIDER: S-EPMC8445392 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature