Revisiting the placental clock: Early corticotrophin-releasing hormone rise in recurrent preterm birth.

ABSTRACT:

Objective

To determine if maternal plasma CRH and preterm birth history were associated with recurrent preterm birth risk in a high-risk cohort.

Study design

Secondary analysis of pregnant women with a prior preterm birth ≤35 weeks receiving 17-alpha hydroxyprogesterone caproate for the prevention of recurrent spontaneous preterm birth. All women with a 24-week blood sample were included. Maternal plasma CRH level at 24- and 32-weeks' gestation was measured using both enzyme-linked immunosorbent assay (ELISA) and extracted radioimmunoassay (RIA) technologies. The primary outcome was spontaneous preterm birth <37 weeks. The association of CRH, prior preterm birth history, and the two combined was assessed in relation to recurrent preterm birth risk.

Results

Recurrent p

SUBMITTER: Herrera CL 

PROVIDER: S-EPMC8445461 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature