A Mathematical Analysis of HDV Genotypes: From Molecules to Cells.

ABSTRACT: Hepatitis D virus (HDV) is classified according to eight genotypes. The various genotypes are included in the HDVdb database, where each HDV sequence is specified by its genotype. In this contribution, a mathematical analysis is performed on RNA sequences in HDVdb. The RNA folding predicted structures of the Genbank HDV genome sequences in HDVdb are classified according to their coarse-grain tree-graph representation. The analysis allows discarding in a simple and efficient way the vast majority of the sequences that exhibit a rod-like structure, which is important for the virus replication, to attempt to discover other biological functions by structure consideration. After the filtering, there remain only a small number of sequences that can be checked for their additional stem-loo

SUBMITTER: Zakh R 

PROVIDER: S-EPMC8445514 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature