A Multiscale Agent-Based Model of Ductal Carcinoma In Situ.

ABSTRACT:

Objective

we present a multiscale agent-based model of Ductal Carcinoma in Situ (DCIS) in order to gain a detailed understanding of the cell-scale population dynamics, phenotypic distributions, and the associated interplay of important molecular signaling pathways that are involved in DCIS ductal invasion into the duct cavity (a process we refer to as duct advance rate here).

Methods

DCIS is modeled mathematically through a hybridized discrete cell-scale model and a continuum molecular scale model, which are explicitly linked through a bidirectional feedback mechanism.

Results

we find that duct advance rates occur in two distinct phases, characterized by an early exponential population expansion, followed by a long-term steady linear phase of population expansion, a r

SUBMITTER: Butner JD 

PROVIDER: S-EPMC8445608 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature