Immunotherapy in microsatellite instability metastatic colorectal cancer: Current status and future perspectives.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most frequent and deadly malignancies worldwide. This specific pathology is composed of various molecular entities, with distinct immunological phenotypes. In addition to KRAS, NRAS, and BRAF mutation status, other druggable alterations such as those in HER2, MET, NTRK, ALK, and ROS1 have been identified in recent years offering new therapeutic options for some patients with CRC.

Aim

This review will focus on the molecular biology, immunological fingerprints, and current clinical evidence for the use of immunotherapy in patients with CRC.

Relevance for patients

High microsatellite instability (MSI-H) and mutations in mismatch repair genes constitute a new molecular entity within CRC, which is characterized by a high mut

SUBMITTER: Motta R 

PROVIDER: S-EPMC8445628 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature