Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.

ABSTRACT:

Objective

To compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage throughout the first trimester.

Design

Prospective, nested case-control study.

Setting

Tertiary Centre, Queen Charlotte Hospital, London, United Kingdom.

Patient(s)

Adult women who had miscarriages (n = 95, 173 samples) and women with healthy pregnancies (n = 265, 557 samples).

Intervention(s)

The participants underwent serial ultrasound scans and blood sampling for measurement of plasma kisspeptin and βhCG levels during the first trimester.

Main outcome measure(s)

The ability of plasma kisspeptin and βhCG levels to distinguish pregnancies complicated by miscarriage from healthy pregnancies u

SUBMITTER: Abbara A 

PROVIDER: S-EPMC8445632 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature