Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment.

ABSTRACT: Chronic Liver Diseases (CLD) are characterized by abnormal accumulation of collagen fibrils, neo-angiogenesis, and sinusoidal remodeling. Collagen deposition along with intrahepatic angiogenesis and sinusoidal remodeling alters sinusoid structure resulting in portal hypertension, liver failure, and other complications. Efforts were made to develop treatments for CLDs. However, the success of such treatments is limited and unpredictable. We report a strategy for CLD treatment by induction of integrin α_vβ₃ mediated cell apoptosis using a rationally designed protein (ProAgio). ProAgio is designed to target integrin α_vβ₃ at a novel site. Integrin α_vβ₃ is highly expressed in activated Hepatic Stellate Cells (HSC), angiogenic endo

SUBMITTER: Turaga RC 

PROVIDER: S-EPMC8445973 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature