Ontology highlight
ABSTRACT:
SUBMITTER: Binder S
PROVIDER: S-EPMC8446032 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Binder Stefanie S Zipfel Ivonne I Müller Claudia C Wiedemann Karolin K Schimmelpfennig Carolin C Pfeifer Gabriele G Reiche Kristin K Hauschildt Sunna S Lehmann Jörg J Köhl Ulrike U Horn Friedemann F Friedrich Maik M
Scientific reports 20210916 1
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor, characterized by its high genetic heterogeneity. In search of novel putative therapeutic RNA targets we investigated the role of the oncogenic long noncoding RNA LINC00152 (CYTOR, and STAiR18) in A172 glioblastoma cells. Here, we are the first to describe, that LINC00152 unexpectedly acts in a tumor suppressive manner in this cell line. SiRNA-based knockdown of LINC00152 enhanced malignant tumor behaviors including proliferati ...[more]