Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis.

ABSTRACT:

Aims

Anti-leucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis (AE) is characterized by complex manifestations of seizures. Here, we report a new seizure semiology, attempt to classify the disease by semiology type, and explore the metabolic pattern of each group.

Methods

Anti-LGI1 AE patients were retrospectively screened between May 2014 and September 2019 in our tertiary epilepsy center. All enrolled patients had seizures during long-range video electroencephalogram (EEG) recordings, and all patients (except one) underwent [¹⁸ F] fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) scans. Voxel-based metabolic analysis and z-distribution analysis were carried out to determine the metabolic pattern.

Results

Thirty-three patients were

SUBMITTER: Li TR 

PROVIDER: S-EPMC8446218 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature