Pan-Cancer Analysis of Atrial-Fibrillation-Related Innate Immunity Gene ANXA4.

ABSTRACT: Background: Atrial fibrillation (AF) is the most common tachyarrhythmia around the world. Cancer is one of the main causes of death worldwide. A recent study demonstrated that cancer was associated with an increased incidence of AF. In the present study, we aimed to explore possible mechanisms and potential common therapeutic targets between AF and cancer. Methods: Differentially expressed proteins between AF and sinus rhythm were identified utilizing proteomics analysis. Weighted gene correlation network analysis was applied to cluster proteins into different modules and investigate associations between modules and AF. Hub immune-related genes were selected via InnateDB database and verified using qRT-PCR. RNA sequencing and clinical data of 33 different cancer types were ac

SUBMITTER: Yan T 

PROVIDER: S-EPMC8446278 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature