Quantitative Pupillometry as a Predictor of Pediatric Postoperative Opioid-Induced Respiratory Depression.

ABSTRACT:

Background

Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification of children at risk for postoperative respiratory depression (RD) will help tailor analgesic therapy and significantly improve the safety of opioids in children. Quantitative pupillometry (QP) is a noninvasive, objective, and real-time tool for monitoring CNS effect-time relationship of opioids. This exploratory study aimed to determine the association of QP measures with postoperative RD, as well as to identify the best intraoperative QP measures predictive of postoperative RD in children.

Methods

After approval from the i

SUBMITTER: Packiasabapathy S 

PROVIDER: S-EPMC8446291 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature