Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates.

ABSTRACT:

Background

Cebranopadol, a mixed nociceptin/opioid receptor full agonist, can effectively relieve pain in rodents and humans. However, it is unclear to what degree different opioid receptor subtypes contribute to its antinociception and whether cebranopadol lacks acute opioid-associated side effects in primates. The authors hypothesized that coactivation of nociceptin receptors and μ receptors produces analgesia with reduced side effects in nonhuman primates.

Methods

The antinociceptive, reinforcing, respiratory-depressant, and pruritic effects of cebranopadol in adult rhesus monkeys (n = 22) were compared with μ receptor agonists fentanyl and morphine using assays, including acute thermal nociception, IV drug self-administration, telemetric measurement of respiratory functi

SUBMITTER: Ding H 

PROVIDER: S-EPMC8446297 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature