Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.

ABSTRACT:

Background

Metastatic castration-resistant prostate cancer remains fatal despite recent advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic castration-resistant prostate cancer. Lutetium-177 (¹⁷⁷Lu)-PSMA-617 is a radioligand therapy that delivers beta-particle radiation to PSMA-expressing cells and the surrounding microenvironment.

Methods

We conducted an international, open-label, phase 3 trial evaluating ¹⁷⁷Lu-PSMA-617 in patients who had metastatic castration-resistant prostate cancer previously treated with at least one androgen-receptor-pathway inhibitor and one or two taxane regimens and who had PSMA-positive gallium-68 (⁶⁸Ga)-labeled PSMA-11 positron-emission tomographic-computed tomographic scans. Pat

SUBMITTER: Sartor O 

PROVIDER: S-EPMC8446332 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature