Resident cardiac macrophages mediate adaptive myocardial remodeling.

ABSTRACT: Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine Receptor 2 positive (CCR2⁺) macrophages derived from infiltrating monocytes regulate myocardial inflammation and heart failure pathogenesis. Comparatively little is known about the functions of tissue resident (CCR2^-) macrophages. Herein, we identified an essential role for CCR2^- macrophages in the chronically failing heart. Depletion of CCR2^- macrophages in mice with dilated cardiomyopathy accelerated mortality and impaired ventricular remodeling and coronary angiogenesis, adaptive changes necessary to maintain cardiac output in the setting of reduced cardiac contractility. Mechanistically,

SUBMITTER: Wong NR 

PROVIDER: S-EPMC8446343 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature