Cyclophilin A: a possible host modulator in Chandipura virus infection.

ABSTRACT: Chandipura virus (CHPV), belonging to the genus Vesiculovirus of the family Rhabdoviridae, has been identified as one of the causes of pediatric encephalitis in India. Currently, neither vaccines nor therapeutic drugs are available against this agent. Considering that the disease progresses very fast with a high mortality rate, working towards the development of potential therapeutics against it will have a public health impact. Although the use of viral inhibitors as antiviral agents is the most common way to curb virus replication, the mutation-prone nature of viruses results in the development of resistance to antiviral agents. The recent development of proteomic platforms for analysis of purified viral agents has allowed certain upregulated host proteins that are involved in the morpho

SUBMITTER: Pavitrakar DV 

PROVIDER: S-EPMC8446474 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature