Umbrella Review on Associations Between Single Nucleotide Polymorphisms and Lung Cancer Risk.

ABSTRACT: The aim is to comprehensively and accurately assess potential relationships between single nucleotide polymorphisms (SNP) and lung cancer (LC) risk by summarizing the evidence in systematic reviews and meta-analyses. This umbrella review was registered with the PROSPERO international prospective register of systematic reviews under registration number CRD42020204685. The PubMed, Web of Science, and Embase databases were searched to identify eligible systematic reviews and meta-analyses from inception to August 14, 2020. The evaluation of cumulative evidence was conducted for associations with nominally statistical significance based on the Venice criteria and false positive report probability (FPRP). This umbrella review finally included 120 articles of a total of 190 SNP. The median numbe

SUBMITTER: Li X 

PROVIDER: S-EPMC8446528 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature