Polygenic Hazard Score Associated Multimodal Brain Networks Along the Alzheimer's Disease Continuum.

ABSTRACT:

Background

Late-onset Alzheimer's disease (AD) is a polygenic neurodegenerative disease. Identifying the neuroimaging phenotypes behind the genetic predisposition of AD is critical to the understanding of AD pathogenesis. Two major questions which previous studies have led to are: (1) should the general "polygenic hazard score" (PHS) be a good choice to identify the individual genetic risk for AD; and (2) should researchers also include inter-modality relationships in the analyses considering these may provide complementary information about the AD etiology.

Methods

We collected 88 healthy controls, 77 patients with mild cognitive impairment (MCI), and 22 AD patients to simulate the AD continuum included from the ADNI database. PHS-guided multimodal fusion was used to invest

SUBMITTER: Li K 

PROVIDER: S-EPMC8446666 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature