Macrolide-associated ototoxicity: a cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss.

ABSTRACT:

Background

Macrolides are widely prescribed antibiotics for many different indications. However, there are concerns about adverse effects such as ototoxicity.

Objectives

To investigate whether macrolide use is associated with tinnitus and hearing loss in the general population.

Methods

Cross-sectional (n = 4286) and longitudinal (n = 636) analyses were performed within the population-based Rotterdam Study. We investigated with multivariable logistic regression models the association between macrolides and tinnitus, and with multivariable linear regression models the association between macrolides and two different hearing thresholds (both ears, averaged over 0.25, 0.5, 1, 2, 4 and 8 kHz and 2, 4 and 8 kHz). Both regression models were adjusted for age, sex, systolic b

SUBMITTER: Vanoverschelde A 

PROVIDER: S-EPMC8446930 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature