COVID-19: Histopathological correlates of imaging patterns on chest computed tomography.

ABSTRACT:

Background and objective

Patients with coronavirus disease 2019 (COVID-19) pneumonia present with typical findings on chest computed tomography (CT), but the underlying histopathological patterns are unknown. Through direct regional correlation of imaging findings to histopathological patterns, this study aimed to explain typical COVID-19 CT patterns at tissue level.

Methods

Eight autopsy cases were prospectively selected of patients with PCR-proven COVID-19 pneumonia with varying clinical manifestations and causes of death. All had been subjected to chest CT imaging 24-72 h prior to death. Twenty-seven lung areas with typical COVID-19 patterns and two radiologically unaffected pulmonary areas were correlated to histopathological findings in the same lung regions.

Results

SUBMITTER: Kianzad A 

PROVIDER: S-EPMC8447040 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature