PAI-1 Polymorphisms Have Significant Associations With Cancer Risk, Especially Feminine Cancer.

ABSTRACT:

Background

The plasminogen activator inhibitor-1 (PAI-1) was found in many types of tumor cells, which involved in tumorigenesis. Some studies investigated the associations between PAI-1 polymorphisms and various cancers, but the results were inconsistent. So this study did a meta-analysis to assess the strength of relationship between PAI-1 and cancer.

Methods

Articles that meet the requirements were searched from PubMed, EMBASE, MEDLINE, Scopus, CNKI, Wanfang and SinoMed electronic databases before June 17th 2021. Stata version 11.2 was performed to merge the odds ratios (ORs) values and calculate 95% confidence intervals (CIs). Stratified analyses were assessed on the basis of types of cancer, ethnicity and source of the control group. Heterogeneity and sensitivity analys

SUBMITTER: Wang J 

PROVIDER: S-EPMC8447096 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature