Dissecting the Binding Profile of PET Tracers to Corticobasal Degeneration Tau Fibrils.

ABSTRACT: Alzheimer's disease and primary tauopathies are characterized by the presence of tau pathology in brain. Several tau positron emission tomography (PET) tracers have been developed and studied in Alzheimer's disease (AD), but there is still a lack of 4R-tau specific tracers for non-AD tauopathies. We here present the first computational study on the binding profiles of four tau different PET tracers, PI2620, CBD2115, PM-PBB3, and MK6240, to corticobasal degeneration (CBD) tau. The in silico results showed different preferences for the various binding sites on the 4R fibril, and especially an entry site, a concave site, and a core site showed high binding affinity to these tracers. The core site and entry site both showed higher binding affinity than the surface sites, but the tracers

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8447187 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature