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Human models for COVID-19 research.

ABSTRACT: Currently, therapeutics for COVID-19 are limited. To overcome this, it is important that we use physiologically relevant models to reproduce the pathology of infection and evaluate the efficacy of antiviral drugs. Models of airway infection, including the use of a human infection challenge model or well-defined, disease relevant in vitro systems can help determine the key components that perpetuate the severity of the disease. Here, we briefly review the human models that are currently being used in COVID-19 research and drug development.

SUBMITTER: Woodall MNJ

PROVIDER: S-EPMC8447334 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Human models for COVID-19 research.

Woodall Maximillian N J MNJ Masonou Tereza T Case Katie-Marie KM Smith Claire M CM

The Journal of physiology 20210817 18

Currently, therapeutics for COVID-19 are limited. To overcome this, it is important that we use physiologically relevant models to reproduce the pathology of infection and evaluate the efficacy of antiviral drugs. Models of airway infection, including the use of a human infection challenge model or well-defined, disease relevant in vitro systems can help determine the key components that perpetuate the severity of the disease. Here, we briefly review the human models that are currently being use ...[more]

PMID: 34287894

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