A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Tumor protein p53 (TP53) is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSC), and TP53 mutations are associated with inhibited immune signatures and poor prognosis. We established a TP53 mutation associated risk score model to evaluate the prognosis and therapeutic responses of patients with HNSC.

Methods

Differentially expressed genes between patients with and without TP53 mutations were determined by using data from the HNSC cohort in The Cancer Genome Atlas database. Patients with HNSC were divided into high- and low-risk groups based on a prognostic risk score that was generated from ten TP53 mutation associated genes via the multivariate Cox regression model.

Results

TP53 was the most common mutant gene in HNSC, and TP53

SUBMITTER: Shi C 

PROVIDER: S-EPMC8447564 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature