Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.

ABSTRACT: Host-virus protein-protein interactions play key roles in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a comprehensive interactome study between the virus and host cells using tandem affinity purification and proximity-labeling strategies and identified 437 human proteins as the high-confidence interacting proteins. Further characterization of these interactions and comparison to other large-scale study of cellular responses to SARS-CoV-2 infection elucidated how distinct SARS-CoV-2 viral proteins participate in its life cycle. With these data mining, we discovered potential drug targets for the treatment of COVID-19. The interactomes of two key SARS-CoV-2-encoded viral proteins, NSP1 and N, were compared with the interactomes of their counte

SUBMITTER: Chen Z 

PROVIDER: S-EPMC8447597 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature