High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common and fatal cancers worldwide. Effective biomarkers to aid the early diagnosis of GC, as well as predict the course of disease, are urgently needed. Hence, we explored the role and function of cadherin-6 (CDH6) in the diagnosis and prognosis of gastric cancer.

Methods

The expression levels of CDH6 in cancerous and normal gastric tissue were analyzed using multiple public databases. Gene set enrichment analysis (GSEA) was performed using The Cancer Genome Atlas (TCGA) dataset. The diagnostic efficiency of CDH6 expression in GC patients was determined through receiver operating characteristic (ROC) curve analysis. The associations between clinical variables and CDH6 expression were evaluated statistically, and the prognost

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC8447617 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature