Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.

ABSTRACT:

Background and objective

Sympathetic activity plays an important role in the proliferation and differentiation of stem cells, and it changes over time, thereby exerting differential effects on various stem cell types. Aging causes sympathetic hyperactivity in aged tissues and blunts sympathetic nerves regulation, and sympathetic abnormalities play a role in aging-related diseases. Currently, the effect of sympathetic activity on skeletal muscle stem cells, namely satellite cells (SCs), is unclear. This study aimed to investigate the effects of skeletal muscle sympathetic activity on SC aging and skeletal muscle repair.

Materials and methods

To evaluate skeletal muscle and fibrotic areas, numbers of SCs and myonuclei per muscle fiber, β2-adrenoceptor (β2-ADR) expression, musc

SUBMITTER: Yuan S 

PROVIDER: S-EPMC8447727 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature