Association between low-density cholesterol change and outcomes in acute ischemic stroke patients who underwent reperfusion therapy.

ABSTRACT:

Background

Low-density lipoprotein cholesterol (LDL-C) can increase cardiovascular risk. However, the association between LDL-C change and functional outcomes in acute ischemic stroke (AIS) patients who underwent reperfusion therapy remains unclear.

Methods

Patients who received reperfusion therapy were consecutively enrolled. LDL-C measurement was conducted at the emergency department immediately after admission and during hospitalization. The change of LDL-C level (ΔLDL-C) was calculated by subtracting the lowest LDL-C among all measurements during hospitalization from the admission LDL-C. Poor functional outcome was defined as modified Rankin Scale (mRS) > 2 at 90 days.

Results

A total of 432 patients were enrolled (mean age 69.2 ± 13.5 years, 54.6 % males). The me

SUBMITTER: Cui T 

PROVIDER: S-EPMC8447794 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature