Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.

ABSTRACT:

Background

Clostridioides difficile infection (CDI) is an infectious nosocomial disease caused by Clostridioides difficile, an opportunistic pathogen that occurs in the intestine after extensive antibiotic regimens.

Results

Nine C. difficile strains (CBA7201-CBA7209) were isolated from nine patients diagnosed with CDI at the national university hospital in Korea, and the whole genomes of these strains were sequenced to identify their genomic characteristics. Comparative genomic analysis was performed using 51 reference strains and the nine isolated herein. Phylogenetic analysis based on 16S rRNA gene sequences confirmed that all 60 C. difficile strains belong to the genus Clostridioides, while core-genome tree indicated that they were divided into five groups, which was cons

SUBMITTER: Ahn SW 

PROVIDER: S-EPMC8447795 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature