Molecular characterization of colorectal cancer: A five-gene prognostic signature based on RNA-binding proteins.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common cancers worldwide. RNA-binding proteins (RBPs) regulate essential biological processes and play essential roles in a variety of cancers. The present study screened differentially expressed RBPs, analyzed their function and constructed a prognostic model to predict the overall survival of patients with CRC.

Methods

We downloaded CRC RNA-sequencing data from the Cancer Genome Atlas (TCGA) portal and screened differentially expressed RBPs. Then, functional analyses of these genes were performed, and a risk model was established by multivariate Cox regression.

Results

We obtained 132 differentially expressed RBPs, including 66 upregulated and 66 downregulated RBPs. Functional analysis revealed that these genes w

SUBMITTER: Liang Q 

PROVIDER: S-EPMC8448017 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature