Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis.

ABSTRACT:

Rationale

Hypertrophied hearts switch from mainly using fatty acids (FAs) to an increased reliance on glucose for energy production. It has been shown that preserving FA oxidation (FAO) prevents the pathological shift of substrate preference, preserves cardiac function and energetics, and reduces cardiomyocyte hypertrophy during cardiac stresses. However, it remains elusive whether substrate metabolism regulates cardiomyocyte hypertrophy directly or via a secondary effect of improving cardiac energetics.

Objective

The goal of this study was to determine the mechanisms of how preservation of FAO prevents the hypertrophic growth of cardiomyocytes.

Methods and results

We cultured adult rat cardiomyocytes in a medium containing glucose and mixed-chain FAs and induced path

SUBMITTER: Ritterhoff J 

PROVIDER: S-EPMC8448129 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature