Metabolic control of T_FH cells and humoral immunity by phosphatidylethanolamine.

ABSTRACT: T follicular helper (T_FH) cells are crucial for B cell-mediated humoral immunity¹. Although transcription factors such as BCL6 drive the differentiation of T_FH cells^2,3, it is unclear whether and how post-transcriptional and metabolic programs enforce T_FH cell programming. Here we show that the cytidine diphosphate (CDP)-ethanolamine pathway co-ordinates the expression and localization of CXCR5 with the responses of T_FH cells and humoral immunity. Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of T_FH cell differenti

SUBMITTER: Fu G 

PROVIDER: S-EPMC8448202 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature