The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided caudal block in anorectal surgery. A dose finding study.

ABSTRACT:

Background

Caudal epidural block (CEB) provides reliable anesthesia for adults undergoing anorectal surgery. Despite the widely utilization, the minimum effective concentration for 90% patients (MEC90) of ropivacaine for CEB remains unknown.

Objective

To estimate MEC of ropivacaine for CEB in anorectal surgery.

Design

A prospective dose-finding study using biased coin design up-and-down sequential method.

Setting

Operating room and postoperative recovery area of Chengdu Shangjin Nanfu Hospital, from October 2019 to January 2020.

Patients

50 males and 51 females scheduled for anorectal surgery.

Interventions

We conducted two independent biased coin design up-and down trials by genders. The concentration of ropivacaine administered to the first pati

SUBMITTER: Li X 

PROVIDER: S-EPMC8448308 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature