Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.

ABSTRACT: Chlamydia trachomatis is a common sexually transmitted infection that is associated with a range of serious reproductive tract sequelae including in women Pelvic Inflammatory Disease (PID), tubal factor infertility, and ectopic pregnancy. Ascension of the pathogen beyond the cervix and into the upper reproductive tract is thought to be necessary for these pathologies. However, Chlamydia trachomatis does not encode a mechanism for movement on its genome, and so the processes that facilitate ascension have not been elucidated. Here, we evaluate the factors that may influence chlamydial ascension in women. We constructed a mathematical model based on a set of stochastic dynamics to elucidate the moderating factors that might influence ascension of infections in the first month of an infection

SUBMITTER: Callan T 

PROVIDER: S-EPMC8448331 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature