Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C.

ABSTRACT: Although combination antiretroviral therapies seem to be effective at controlling HIV-1 infections regardless of the viral subtype, there is increasing evidence for subtype-specific drug resistance mutations. The order and rates at which resistance mutations accumulate in different subtypes also remain poorly understood. Most of this knowledge is derived from studies of subtype B genotypes, despite not being the most abundant subtype worldwide. Here, we present a methodology for the comparison of mutational networks in different HIV-1 subtypes, based on Hidden Conjunctive Bayesian Networks (H-CBN), a probabilistic model for inferring mutational networks from cross-sectional genotype data. We introduce a Monte Carlo sampling scheme for learning H-CBN models for a larger number of resistance

SUBMITTER: Posada-Cespedes S 

PROVIDER: S-EPMC8448360 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature