Plasma lipids and growth faltering: A longitudinal cohort study in rural Gambian children.

ABSTRACT: Growth faltering in children arises from metabolic and endocrine dysfunction driven by complex interactions between poor diet, persistent infections, and immunopathology. Here, we determined the progression of the plasma lipidome among Gambian children (n = 409) and assessed its association with growth faltering during the first 2 years of life using the panel vector autoregression method. We further investigated temporal associations among lipid clusters. We observed that measures of stunting, wasting, and underweight are dynamically associated with each other and that lipid groups containing polyunsaturated fatty acids (PUFAs) and phosphatidylcholines consistently predict future growth outcomes. Linear growth was dynamically associated with the majority of lipids, indicating a hig

SUBMITTER: Gonzales GB 

PROVIDER: S-EPMC8448443 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature