Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.

ABSTRACT: The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging, bone marrow chimeras, and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvarial-meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells, wh

SUBMITTER: Brioschi S 

PROVIDER: S-EPMC8448524 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature