Ontology highlight
ABSTRACT:
SUBMITTER: Daneva Z
PROVIDER: S-EPMC8448527 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Daneva Zdravka Z Ottolini Matteo M Chen Yen Lin YL Klimentova Eliska E Kuppusamy Maniselvan M Shah Soham A SA Minshall Richard D RD Seye Cheikh I CI Laubach Victor E VE Isakson Brant E BE Sonkusare Swapnil K SK
eLife 20210907
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor potential vanilloid 4 (TRPV4) channels lower pulmonary artery (PA) contractility and exogenous ATP activates endothelial TRPV4 channels. We hypothesized that endothelial Panx1-ATP-TRPV4 channel signaling promotes vasodilation and lowers pulmonary arterial pressure (PAP) ...[more]