Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts.

ABSTRACT: The liver is an important metabolic organ that controls homeostasis in the body. Moreover, it functions as a hematopoietic organ, while its metabolic function is low during development. Hepatocytes, which are parenchymal cells of the liver, acquire various metabolic functions by the maturation of hepatic progenitor cells during the fetal period; however, this molecular mechanism is still unclear. In this study, Kruppel-like factor 15 (KLF15) was identified as a new regulator of hepatic maturation through a comprehensive analysis of the expression of transcriptional regulators in mouse fetal and adult hepatocytes. KLF15 is a transcription factor whose expression in the liver increases from the embryonic stage throughout the developmental process. KLF15 induced the overexpression of liver fu

SUBMITTER: Anzai K 

PROVIDER: S-EPMC8448749 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature