Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.

ABSTRACT: There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identifying translatable neurophysiological signals that are related to specific behavioral constructs. Here, we present evidence from three paradigms that were completed by humans and mice using analogous procedures, with each task eliciting candidate a priori defined electrophysiological signals underlying effortful motivation, reinforcement learning, and cognitive control. The effortful motivation was assessed using a progressive ratio breakpoint task, yielding a similar decrease in alpha-band activity over time in both species. Reinforcement learni

SUBMITTER: Cavanagh JF 

PROVIDER: S-EPMC8448772 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature