Axonal degeneration induces distinct patterns of phosphatidylserine and phosphatidylethanolamine externalization.

ABSTRACT: Axonal degeneration is a common feature of multiple neurodegenerative diseases, yet the mechanisms underlying its various manifestations are incompletely understood. We previously demonstrated that axonal degeneration is associated with externalization of phosphatidylserine (PS), which precedes morphological evidence of degeneration, is redox-sensitive, and is delayed in Wallerian degeneration slow (Wld^S) mutant animals. Phosphatidylethanolamine (PE) is the other major membrane phospholipid in the inner leaflet of the cell membrane, and given that PS signals apoptosis, phagocytosis, and degeneration, we hypothesized that PS and PE membrane dynamics play distinct roles in axonal degeneration. To test this hypothesis, axonal degeneration was induced with calcium ionophores in post

SUBMITTER: Faris H 

PROVIDER: S-EPMC8448818 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature