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Interleukin-34 promotes tumorigenic signals for colon cancer cells.

ABSTRACT: Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate or suppress CRC cell growth and survival, mainly via the production of cytokines. Interleukin-34 (IL-34), a cytokine known to regulate mainly monocyte/macrophage survival and function, is highly produced within the CRC microenvironment by several cell types, including cancer cells, tumour-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), and regulates the pro-tumoural functions of such cells. In this article, we summarize the available data supporting the multiple effects of IL-34 in human CRC.

SUBMITTER: Franze E

PROVIDER: S-EPMC8448832 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Interleukin-34 promotes tumorigenic signals for colon cancer cells.

Franzè Eleonora E Marafini Irene I Troncone Edoardo E Salvatori Silvia S Monteleone Giovanni G

Cell death discovery 20210917 1

Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate or suppress CRC cell growth and survival, mainly via the production of cytokines. Interleukin-34 (IL-34), a cytokine known to regulate mainly monocyte/macrophage survival and function, is highly produced within the CRC microenvironment by severa ...[more]

PMID: 34535634

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Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue.

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Correction: Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity.

Project description: Not available

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Interleukin-34-CSF1R Signaling Axis Promotes Epithelial Cell Transformation and Breast Tumorigenesis.

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| S-EPMC7962444 | biostudies-literature

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