Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

ABSTRACT: Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and spinal cord has not been systematically investigated in mice and humans. Furthermore, it is unknown whether scar-forming stromal cells have the same origin throughout the central nervous system and in different types of lesions. In the current study, we compared fibrotic scarring in human pathological tissue and corresponding mouse models of penetrating and non-penetrating spinal cord injury, traumatic brain injury, ischemic stroke, multiple sclerosis and glioblastoma. We show that the extent and distribution of stromal cells are specific to the type of lesion and, in most cases, similar betwee

SUBMITTER: Dias DO 

PROVIDER: S-EPMC8448846 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature