Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway.

ABSTRACT: Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological disorders that share common clinical features, such as language impairment, executive functions, and motor problems. A genetic convergence has been proposed as well. However, the molecular mechanisms of these pathologies are still not well understood. Protein S-nitrosylation (SNO), the nitric oxide (NO)-mediated posttranslational modification, targets key proteins implicated in synaptic and neuronal functions. Previously, we have shown that NO and SNO are involved in the InsG3680(+/+) ASD and P301S AD mouse models. Here, we performed large-scale computational biology analysis of the SNO-proteome followed by biochemical validation to decipher the shared mechanisms between the pathologies. This analysi

SUBMITTER: Mencer S 

PROVIDER: S-EPMC8448888 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature