Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.

ABSTRACT:

Objectives

Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and validate a first-in-class host response bacterial/viral test.

Design

Subjects were recruited from 2006 to 2016. Enrollment blood samples were collected in an RNA preservative and banked for later testing. The reference standard was an expert panel clinical adjudication, which was blinded to gene expression and procalcitonin results.

Setting

Four U.S. emergency departments.

Patients

Six-hundred twenty-three subjects with acute respiratory illness or suspected sepsis.

Interventions

Forty-five-transcript signature measured on the BioFire FilmArray

SUBMITTER: Tsalik EL 

PROVIDER: S-EPMC8448917 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature