Lopinavir and tenofovir interaction observed in non-pregnant adults altered during pregnancy.

ABSTRACT:

What is known and objective

Tenofovir exposure is increased in non-pregnant adults when tenofovir disoproxil fumarate is coadministered with lopinavir/ritonavir. In pregnant women, tenofovir exposure is decreased. Our objective is to describe the effect of lopinavir/ritonavir on tenofovir pharmacokinetics during pregnancy.

Methods

Data were collected through the International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) Network P1026s protocol. This was a nonrandomized, open-label, parallel-group and multicentre phase-IV prospective study in pregnant women with HIV. Intensive steady-state 24-h pharmacokinetic profiles were collected during the third trimester of pregnancy and postpartum. Tenofovir was measured in plasma using validated liquid chromatograp

SUBMITTER: Mulligan N 

PROVIDER: S-EPMC8448937 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature