Modification of Pathologic T Classification for Non-small Cell Lung Cancer With Visceral Pleural Invasion: Data From 1,055 Cases of Cancers ≤ 3 cm.

ABSTRACT:

Background

Visceral pleural invasion (VPI) with PL1 or PL2 increases the T classification from T1 to T2 in non-small cell lung cancers (NSCLCs) ≤ 3 cm. We proposed a modified T classification based on VPI to guide adjuvant therapy.

Research question

Is it reasonable to upstage PL1-positive cases from T1 to T2 for NSCLCs ≤ 3 cm?

Study design and methods

In total, 1,055 patients with resected NSCLC were retrospectively included. Tumor sections were restained with hematoxylin and eosin stain and Victoria blue elastic stain for the elastic layer. Disease-free survival (DFS) and overall survival (OS) were calculated by the Kaplan-Meier method. Subgroup analysis and a Cox proportional hazards model were used to further determine the impact of VPI on survival.

Results

SUBMITTER: Liang RB 

PROVIDER: S-EPMC8449009 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature